However, when taken as prescribed by people with opioid use disorder, methadone and buprenorphine prevent drug cravings and withdrawal symptoms without causing the intense feelings of pleasure (or “high”) that other opioid drugs produce. However, starting naltrexone treatment may be harder for people using opioid drugs than starting buprenorphine or methadone treatment. For people with addictions to drugs like stimulants or cannabis, no medications are currently available to assist in treatment, so treatment consists of behavioral therapies. Research on the science of addiction and the treatment of substance use disorders has led to the development of research-based methods that help people to stop using drugs and resume productive lives, also known as being in recovery. Both methadone and buprenorphine bind to and activate the same mu-opioid receptors in the brain as do other opioid drugs. Like methadone, buprenorphine can reduce cravings and withdrawal symptoms without producing intense feelings of pleasure and intoxication in people who have opioid use disorder.

Are medications for opioid use disorder addictive?

• When a person suddenly stops taking their medication abruptly, they may experience withdrawal symptoms.
• One of the brain areas still maturing during adolescence is the prefrontal cortex—the part of the brain that allows people to assess situations, make sound decisions, and keep emotions and desires under control.
• Some people may start to feel the need to take more of a drug or take it more often, even in the early stages of their drug use.
• NIDA explores in this video the intriguing similarities between the processes of brain development and computer…

Addiction is a chronic disease characterized by drug seeking and use that is compulsive, or difficult to control, despite harmful consequences. Drugs change the brain in ways that make quitting hard, even for those who want to.

Medications for Opioid Use Disorder

In other cases, drug use may trigger or worsen those mental health conditions, particularly in people with specific vulnerabilities.43,44 In addition, some drugs, such as inhalants, may damage or destroy nerve cells, either in the brain or the peripheral nervous system (the nervous system outside the brain and spinal cord). Because addiction can affect so many aspects of a person’s life, treatment should address the needs of the whole person to be successful. Behavioral therapies can also enhance the effectiveness of medications and help people remain in treatment longer. When a person recovering from an addiction relapses, it indicates that the person needs to speak with their doctor to resume treatment, modify it, or try another treatment.52

Despite these advances, we still do not fully understand why some people develop an addiction to drugs or how drugs change the brain to foster compulsive drug use. Behavioral therapies help people in drug addiction treatment modify their attitudes and behaviors related to drug use. As with other diseases and disorders, the likelihood of developing an addiction differs from person to person, and no single factor determines whether a person will become addicted to drugs. Surges of dopamine in the reward circuit cause the reinforcement of pleasurable but unhealthy behaviors like taking drugs, leading people to repeat the behavior again and again.

Understanding Drug Use and Addiction DrugFacts

In general, the more risk factors a person has, the greater the chance that taking drugs will lead to drug use and addiction. Brain imaging studies of people with addiction show physical changes in areas of the brain that are critical to judgment, decision-making, learning and memory, and behavior control.12 These changes help explain the compulsive nature of addiction. Teachers, parents, and health care providers have crucial roles in educating young people and preventing drug use and addiction. The more risk factors a person has, the greater the chance that taking drugs can lead to addiction.

Reflecting on NIDA’s 50th year and looking to 2025

• Medications for opioid use disorder are safe, effective, and save lives.
• Beyond the harmful consequences for the person with the addiction, drug use can cause serious health problems for others.
• So, I will say, for me, when I was 14 years old I had no idea what addiction was.
• However, these effects are milder than those produced by dependence on other opioid drugs and can be managed by slowly reducing the medication dose rather than stopping it abruptly.
• An official website of the United States government

This booklet aims to fill that knowledge gap by providing scientific information about the disorder of drug addiction, including the many harmful consequences of drug use and the basic approaches that have been developed to prevent and treat substance use disorders. Today, thanks to science, our views and our responses to addiction and the broader spectrum of substance use disorders have changed dramatically. Those views shaped society’s responses to drug use, treating it as a moral failing rather than a health problem, which led to an emphasis on punishment rather than prevention and treatment. When scientists began to study addictive behavior in the 1930s, people with an addiction were thought to be morally flawed and lacking in willpower. For much of the past century, scientists studying drugs and drug use labored in the shadows of powerful myths and misconceptions about the nature of addiction. New NIDA animation tackles a common question and explains the science behind drug use and addiction to help light the…

Treatment should be tailored to address each patient’s drug use patterns and drug-related medical, mental, and social problems. Medications are also available to help treat addiction to alcohol and nicotine. Relapse rates for drug use are similar to rates for other chronic medical illnesses. Protective factors, on the other hand, reduce a person’s risk.

National Advisory Council on Drug Abuse: Open Session – February 2026

When people start opioid use disorder treatment, they usually must go to a program location every day or almost every day to receive their medication. In the United States, methadone is only available from approved opioid treatment programs when used to treat opioid use disorder. Methadone is an opioid medication that has been used for more than 50 years to treat opioid use disorder.4  It binds to and activates the same molecules on neurons (nerve cells), called mu-opioid receptors, as heroin, fentanyl, and other opioid drugs. A person is diagnosed with opioid use disorder if they have two or more of the symptoms and behaviors related to their opioid use listed in the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders, 5th Edition.

Video: Why are Drugs So Hard to Quit?

Biological factors that can affect a person’s risk of addiction include their genes, stage of development, or ethnicity. The initial decision to take drugs is typically voluntary. Occasional drug use, such as misusing an opioid to get high, can have similarly disastrous effects, including impaired driving and overdose.

Other products contain buprenorphine together with the overdose-reversal medication naloxone, including tablets or film to put under the tongue or film to place in the cheeks.9 We have identified many of the biological and environmental risk factors and are beginning to search for the genetic variations that contribute to the development and progression of the disorder. Increasing the number of people achieving long-term recovery from SUDs is a national policy priority and a major goal of… Developing an FDA-approved e-cigarette for smoking cessation could improve public health.

Drug Misuse and Addiction

This may exacerbate their mental disorder in the long run, as well as increase addiction specialist degrees, certifications, and qualifications the risk of developing addiction.43,44 Treatment for all conditions should happen concurrently. In some cases, mental disorders such as anxiety, depression, or schizophrenia may come before addiction. Detoxification alone without subsequent treatment generally leads to resumption of drug use. An overdose happens when the person uses enough of a drug to produce uncomfortable feelings, life-threatening symptoms, or death. If a person uses as much of the drug as they did before quitting, they can easily overdose because their bodies are no longer adapted to their previous level of drug exposure.

Studies show that the majority of people who misuse buprenorphine do so to control withdrawal symptoms form other opioids, not to experience a high.25, 26 However, these effects are milder than those produced by dependence on other opioid drugs and can be managed by slowly reducing the medication dose rather than stopping it abruptly. Like many medications, methadone and buprenorphine do produce dependence.

Most drugs affect the brain’s “reward circuit,” causing euphoria as well as flooding it with the chemical messenger dopamine. Many people don’t understand why or how other people become addicted to drugs. Share sensitive information only on official, secure websites. Your role in the treatment of addiction is a primary one and you will be on the front lines of saving lives.

However, naltrexone blocks the effects of opioids. Although it also binds to the mu-opioid receptor, naltrexone blocks the receptor, rather than activates it. When a person suddenly stops taking their medication abruptly, they may experience withdrawal symptoms. Any health care provider can prescribe naltrexone.

This makes methadone and buprenorphine less addictive. So, some people may think they are just substituting one drug for another. Buprenorphine treatment can also be started in the emergency department to ease withdrawal and cravings after an overdose.13  This can help motivate people to begin long-term treatment.

Some people may start to feel the need to take more of a drug or take it more often, even in the early stages of their drug use. When they first use a drug, people may perceive what seem to be positive effects. Therefore, education and outreach are key in helping people understand the possible risks of drug use. Results from NIDA-funded research have shown that prevention programs involving families, schools, communities, and the media are effective for preventing or reducing drug use and addiction. More good news is that drug use and addiction are preventable. These brain adaptations often lead to the person becoming less and less able to derive pleasure from other things they once enjoyed, like food, sex, or social activities.